President Palace Hotel is located on Sukhumvit Road Soi 11 in the heart of Bangkok's vibrant Center Business District and with access to business centers, dining, and the most exciting entertainment hot spots. The BTS Skytrain Nana Station and Sukhumvit MRT Station are within easy walking distance.

Nearby on and off ramps to Bangkok's expressway network provide fast, convenient access to the beach resorts or industrial zones east, west, north and south of the city. Don Muang Domestic and Suvarnabhumi International Airports are approximately 40 minutes from the hotel by expressway.